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Rare diseases are characterized by extremely low incidence rate and small number of patients in total. The drugs used to treat rare diseases are called orphan drugs. Currently, 450 kinds of rare skin diseases have been identified, most of which lack in effective treatments. Supported by the policy-making from the country and pushed by all sectors of the society, drugs for rare skin diseases have been emerging continuously recently in China. This paper reviews the current accessibility of the orphan drugs for skin rare diseases that have been approved in China and in other countries and regions for a better understanding of rare dermatosis and orphan drugs for the diseases.
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Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphomas (CTCLs). Most cases of MF display an indolent course during its early stage. However, in some patients, it can progress to the tumor stage with potential systematic involvement and a poor prognosis. SS is defined as an erythrodermic CTCL with leukemic involvements. The pathogenesis of MF and SS is still not fully understood, but recent data have found that the development of MF and SS is related to genetic alterations and possibly to environmental influences. In CTCL, many components interacting with tumor cells, such as tumor-associated macrophages, fibroblasts, dendritic cells, mast cells, and myeloid‐derived suppressor cells, as well as with chemokines, cytokines and other key players, establish the tumor microenvironment (TME). In turn, the TME regulates tumor cell migration and proliferation directly and indirectly and may play a critical role in the progression of MF and SS. The TME of MF and SS appear to show features of a Th2 phenotype, thus dampening tumorrelated immune responses. Recently, several studies have been published on the immunological characteristics of MF and SS, but a full understanding of the CTCL-related TME remains to be determined. This review focuses on the role of the TME in MF and SS, aiming to further demonstrate the pathogenesis of the disease and to provide new ideas for potential treatments targeted at the microenvironment components of the tumor.
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Female , Humans , Male , Asian People , Diagnosis , Fatal Outcome , Lymphoma , Lymphoma, T-Cell, Cutaneous , Mycosis Fungoides , Prognosis , Retrospective Studies , T-LymphocytesABSTRACT
Objective:To investigate the natural course and psychosocial risk factors of depressive symptoms in college freshmen.Methods:Changes in depressive symptoms among college freshmen were observed for two year periods,self-reporting questionnaires were used to collect data every half yearly.The depressive symptoms were assessed with the Centre for Epidemiological Study-Depression Scale,and psychosocial factors were tested as the potential risk factors,rating by Zung Self-Rating Anxiety Scale,Eysenck Personality Questionnaire-Neuroticism Subscale,Rosenberg Self-Esteem Scale,Frost Multidimensional Perfectionism Scale,Parental Rearing Scale,Adolescents Self-Rating Life Events Checklist,Epworth Sleepiness Scale,daytime sleep time,Godin Leisure-Time Exercise Questionnaire.Generalized estimating equations model was used to analyze the date.Results:Totally 1339 college students were recruited in the survey.It was found the depressive scores significantly increased in the second and third surveys,then decreased in the fourth and fifth surveys.Male (Coef=-1.01,SE =0.42,P =0.017),not interested in the major (Coef=3.89,SE =1.42,P =0.006),neuroticism(Coef =0.79,SE =0.23,P =0.001),self-esteem(Coef =-1.57,SE =0.25,P ＜ 0.001),anxiety(Coef =4.79,SE =0.16,P ＜ 0.001),life events (Coef =0.08,SE =0.01,P ＜ 0.00l),daytime sleepiness (Coef =0.80,SE =4.56,P ＜ 0.001) were significantly correlated with depressive symptoms.Conclusion:The first year of college is a critical time in the prevention depression.Not interested in the major,high neuroticism,low self-esteem,anxiety,life events,daytime sleepiness may be risk factors of depressive symptom in college students.
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Objective To describe high-frequency skin ultrasonographic and dermoscopic features of seborrheic keratosis (SK).Methods Between August and December in 2017,46 outpatients with SK were enrolled from the Department of Dermatology of Peking Union Medical College Hospital,and 50 SK lesions were observed by 50-and 20-MHz high-frequency skin ultrasonography and dermoscopy.The highfrequency ultrasonographic and dermoscopic features of SK lesions were summarized and analyzed.Statistical analysis was done by using chi-square test for comparisons of evaluation results of SK lesions between 50-and 20-MHz ultrasonography,and the correspondence between high-frequency skin ultrasonographic and dermoscopic features of SK was analyzed by calculating the simple matching coefficient.Results As 50-and 20-MHz ultrasonography showed,ultrasonographic features of SK lesions from top to bottom were enhanced hyperecho (48/50 vs.39/50,respectively,P =0.007),enhanced hyperechoic masses or spots in the stratum corneum (22/50 vs.11/50,respectively,P =0.019),sound shadows behind the epidermis (34/50 vs.13/50,respectively,P ＜ 0.001),skin lesions with regular shapes and clear borders (46/50 vs.41/50,respectively,P =0.137),heterogeneous hypoechoic areas in the lesions (50/50 vs.47/50,respectively,P =0.079) and internal hyperechoic spots (25/50 vs.2/50,respectively,P ＜0.001),the lesional bottom being at the same level (40/50 vs.36/50,respectively,P =0.349),and reduced dermal echogenicity below the lesion (50/50 vs.28/50,respectively,P ＜ 0.001).In regard to the overall evaluation of the above 8 ultrasonographic characteristics,50-MHz ultrasonography was superior to 20-MHz ultrasonography (P =0.002).The common dermoscopic features of the 50 SK lesions were clear borders (n =50),comedo-like openings (n =45),ridge or cerebriform pattern (n =31),hairpin-like vessels (n =30),multiple milia-like cysts (n =24),moth-eaten border (n =21) and shiny white streaks (n =3).Under 50-and 20-MHz ultrasonography,the simple matching coefficients between enhanced hyperechoic masses or spots in the stratum corneum and comedo-like openings under dermoscopy were 42％ (21) and 20％ (10) respectively,and the simple matching coefficients between internal hyperechoic spots and multiple milialike cysts (＞ 3) under dermoscopy were 58％ (29) and 48％ (24) respectively.Conclusion Highfrequency skin ultrasonography and dermoscopy both are of great value to the assessment of SK lesions,and 50-MHz ultrasonography is superior to 20-MHz ultrasonography for imaging skin lesions.
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Objective To investigate the dermoscopic features of vulvar lichen sclerosus (VLS).Methods Seventeen patients with VLS,who visited the Department of Dermatology of Peking Union Medical College Hospital between August 2015 and June 2017 and underwent dermoscopy and skin histopathological examination,were enrolled into this study.The dermoscopic images of 75 skin lesions were collected and analyzed retrospectively.Results The common dermoscopic features in these VLS lesions included yellowish-white structureless areas (89.3％,67/75),reddish-violet globules or patches (77.3％,58/75),brownish or bluish-gray pigment structures (49％,37/75),shiny white streaks (40％,30/75),dotted vessels with irregular arrangement (28％,21/75),linear vessels (58.7％,44/75),hairpin-like vessels (6.7％,5/75),comma-like vessels (13％,10/75)and branching vessels (20％,15/75).Under dermoscopy,rosette sign could be observed in 3 (4％) lesions,comedo-like openings in 3 (4％) lesions,and keratotic plugs in 1 (1％) lesions.Conclusion Under dermoscopy,VLS is characterized by yellowishwhite structureless areas,reddish-violet globules or patches,pigment structures and vessels with various vessels.
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Objectives: To explore the effect of personality dysfunction on freshmen's mental status. Methods:Cohort study design was applied in the study. Exposure factors were personality dysfunction and intervention. The mental health status of 2516 freshmen was evaluated by Symptom Checklist 90 (SCL-90), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). Relative risk (RR) and attributive risk (AR) were calculated to test the relationship between exposure factors and mental health status. Results: Cohort study showed that RRs of all types of personality dysfunction history in senior high schools developing mental symptoms in the freshman year were between 1. 980 to 10. 167. Interventions to personality dysfunction during high schools had protective effect to the development of mental symptoms. Conclusion: Personality dysfunction isa risk factor of mental symptoms of freshmen. Early intervention could decrease the risk of the mental symptoms.
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Objectives: To implement cost effective evaluation on the interventions to personality dysfunction in adolescents, so as to provide scientific evidences for extending the interventions. Methods: Cost identification, measurement of the cost, and valuing the cost were implemented to calculate the cost of the interventions. Effects of the interventions were measured based on three indicators: (1) differences of the decreasing scores of Personality Diagnostic Questionnaire-4 (PDQ-4) between intervention group and control group from grade one to three, (2) differences of the decrease number of students with personality dysfunction between intervention group and control group from grade one to three, and (3) differences of the incidence of personality dysfunction between intervention group and control group. Cost-effectiveness ratios (CERs) were calculated for the economic evaluation of the interventions. Results: The total cost of the interventions was 67, 860 Yuan. After intervention, among all of the students in intervention group, the cost of reducing one score of PDQ-4 was 9. 25 Yuan. The cost of reducing one person with personality dysfunction was 6169 Yuan. And the cost of avoiding one person developed personality dysfunction was 2714 Yuan. The cost effectiveness were not balanced among Cluster A, Cluster B and Cluster C personality dysfunction. Similar tendency was found among 10 types of personality dysfunction. Conclusion: The "Intervention Measure on Personality Dysfunction" in adolescents is easy to implement and has relative low costs. Further interventions of the specific cluster or type of personality dysfunction can be carried out based on the findings from this study.
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Objectives: To establish an intervention model of mental health education for personality disorders through community intervention study and to provide scientific basis for the early intervention of personality disorders. Methods: In Beijing, students from 25 high schools were selected as subjects of the study. Random cluster sampling method was used to divide all the schools into intervention group (13high schools) and non-intervention group (12 high schools), when the students werein the first grade. All of the schools were followedup for three years. According to the ICD-10 and DSM-IV criteria, PDQ-4 and the International Personality Disorder Checklist (IPDE) were used to screen and diagnose personality disorder. Associated influencing factors were collected using the Parental Rearing Questionnaire (Egma Minnen av Bardndosnauppfor-stran, EMBU) and the General Information Questionnaire. Univariate and multivariate analysis were used to analyze the data. Results: PDQ-4 scores of the intervention group were significantly lower than those of the non-intervention group. PDQ-4 scores and incidence rates of PD at the third grade were significantly lower than those at the first grade. Logistic regression analysis yielded risk factors of overall PD including poor parental relationship, parental rejection and over-protection. The incidence rate of personality dysfunction was 3. 4％ in the intervention group, and 4. 0％ in the non-intervention group. The incidence rate of PD was 0. 8％ in the intervention group, and 1. 1％ in the non-intervention group without statistical significance. The PDQ-4 score showed significant decline trend during the three years. But the prevalence rates had no statistical significant difference between intervention and non-intervention groups. Moreover, the prevalence rate of personality dysfunction significantly decreased after three years. The incidence rates of cluster C, as well as paranoid, narcissistic and borderline PD were statistically significantly decreased after the intervention. Conclusion:The mental health education during adolescence is effective and contributes to the promotion of mental health for adolescents.
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Objectives: To prove the environmental etiological hypothesis of personality disorder and to evaluate the relative risk(RR) of family environmental risk factors for personality disorder. Methods: By means of cohort study, about 9200 senior high school students and their parents had been followed-up for three years by Personality Disorder Questionnaire-fourth edition (PDQ-4), Parental Rearing Questionnaire (Egma Minnen av Bardndosnauppfor-stran, EMBU), General Information Questionnaire, and International Personality Disorder Examination (IPDE) to diagnose PD according to the criteria of ICD-10 and DSM-IV. The univariate and multivariate analysis methods were applied for data processing. Results: The incidence rate of personality dysfunction and personality disorders were 4. 0％ and 1. 1％, respectively. Univariate analysis indicated that the incidence of personality dysfunction had significant statistical association with male, the parental rejection and over-protection, with the Relative Risks being 0. 64, 2. 60 and 2. 31, respectively. Univariate analysis indicated that the incidence of PD had significant statistical association with the parental rejection and over-protection, with the RR being 2. 45 and 2. 80, respectively. Conclusion: The family environmental risk factors are significantly associated with personality disorders.
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Objectives: To explore genetic and environmental risk factors of personality disorder (PD). Methods:By means of case-control study, 10003 senior high school students and their parents were investigated twice in first and third grades using Personality Disorder Questionnaire-fourth edition (PDQ-4), Parental Rearing Questionnaire (Egma Minnen av Bardndosnauppfor-stran, EMBU), General Information Questionnaire, and InternationalPersonality Disorder Examination (IPDE) to diagnose PD according to the criteria of ICD-10 and DSM-IV. The univariate and multivariate analysis methods were applied for data processing. Results: In the students of first grade, the risk factors of personality dysfunction were poor parental relationship, rural residential area, parental rejection, overprotection, favoring subject, non-emotional warmth, shorter time of living with parents, and male. Similar results were yielded instudents of third grades. The risk factors of PD were poor parental relationship, parental rejection, and over-protection. The heritability of overall PD of father and mother were 0. 84 and 0. 85, respectively. The heritability of each PD cluster was higher than 0. 6. Conclusion: The genetic factor plays an important role in the development of PD. Family environmental risk factors include poor parental relationship, parental rejection and over-protection.
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This article reviews studies on the heredity of personality disorders and family environment factors from the population-based studies, and summarizes the interaction between genetic factors and environmental factors. Studies have shown that there is a genetic basis for personality disorders, including family studies, twin studies, and neurophysiological studies. In addition, environmental factors, including social psychological factors, also play an important role in the development of personality disorder. In sum, the occurrence of personality disorder is the result of interactions between genetic factors and environmental factors. This paper snmmarizes sresearch on personality disorders, and investigates the role of interaction between genetic and environmental factors in the development of personality disorders. Such evidence has implications for effective prevention and intervention of personality disorders.
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Objectives: To describe prevalence of personality dysfuction and personality disorders (PD) and their distribution in senior high school students in Beijing. Methods: By means of cross-sectional study, 10003 senior high school students were investigated by Personality Disorder Questionnaire-fourth edition (PDQ-4), Parental Rearing Questionnaire (Egma Minnen av Bardndosnauppfor-stran, EMBU), General Information Questionnaire, and International Personality Disorder Examination (IPDE) to diagnose PD according to the criteria of ICD-10 and DSM-IV. Results: In the students of first grade, the mean score of PDQ-4 was (25. 38 ± 9. 64). Male students had higher PDQ-4 scroes than those of female. Students in rural high schools had higher PDQ-4 scroes than those of students in urban high schools. Students in general high schools had the highest PDQ-4 scroes, followed by students in disctrict-level key high schools, and the students from city-level key high schools had the lowest PDQ-4 scroes. The prevalence rate of personality dysfunction was 8. 3％ with similar distributions of PDQ-4 scroes by gender, residential area, and rank of school. In the students of third grade, the mean score of PDQ-4 was (23. 10 ± 10. 20). Male students had higher PDQ-4 scroes than those of female. The prevalence rates of personality dysfunction and PD were 5. 8％ and 1. 83％, respectively. The correlation coefficients of EMBU had statistical significances and four common factors were identified by factor analysis. The heritability of overall PD of father and mother were 0. 71 and 0. 72, respectively. The heritability of each PD cluster was higher than 0. 6. Conclusion: The prevalence rates of personality dysfunction and personality disorder in Beijing, China is lower than those in other countries. The genetic factor plays an important role in the development of PD.
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Objectives: To describe prevalence of personality disorders (PD) and personality dysfunction in senior high school students in Beijing using cross-sectional study, to explore genetic and environmental risk factors of PD in adolescence using a case-control study, to establishand test the hypothesis of genetic and environmental risk factors of PD using a cohort study and describe the natural history of personality dysfunction, and to develop and test an intervention model of mental health education to community adolescents in Beijing using a community intervention trail. Methods: By means of cross-sectional study, case-control study, cohort study, and community intervention trial, 10003 senior high school students and their parents were investigated by Personality Disorder Questionnaire-fourth edition, Parental Rearing Behavior Questionnaire (Egma Minnen av Bardndosnauppfor-stran, EMBU), General Information Questionnaire, and International Personality Disorder Examination (IPDE) to diagnose PD according to the criteria of ICD-10 and DSM-IV. The subjects were followed-up for three years to observe the dynamic change of personal dysfunction and to evaluate the effect of intervention measure of mental health education. The univariate and multivariate analysis methods were applied for data analyses.
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Objective:To describe the epidemiological characteristics of mental disorders in Ximeng Wa Au-tonomous County and explore psychosocial risk factors of mental disorders. Methods:Two thousand three hundred and eighty one residents aged 1 8 years and over were sampled using multistage sampling in Ximeng Wa Autono-mous County in 2013. All respondents were investigated by face-to-face interview. Mental disorders were screened out by using the General Health Questionnaire (GHQ)and diagnosed according to the International Classification of Diseases Checklist (ICD-10-Checklist)criteria. Results:Life time prevalence of any mental disorder was 19. 86%(419/2110). The lifetime prevalence rates of substance use disorder,anxiety disorder,insomnia,mood disorder, schizophrenia were 12. 99%(274/2110),6. 30%(133/2110),2. 94%(62/2110),2. 32%(49/2110)and 1. 00%(21/2110)respectively. Male (OR=0. 43),older age (35 -49 years,OR=1. 78;50 -64 years,OR=2. 59;≥65 years,OR=3. 5 1 ),unmarried and other marital status (OR=0. 3 1 ),non-Wa and non-Lahu ethnic groups (OR=0. 29)were associated with neurotic,stress-related and somatoform disorders. Male (OR=2. 41),older age (35 -49 years,OR=2. 29;50-64 years,OR=3. 20;≥65 years,OR=4. 58),non-farmer and non-self-employed occupation (OR=0. 41),and non-Wa and non-Lahu ethnic groups (OR=0. 32)were associated with psychoactive substance use disorder. Male (OR =0. 35 ) and order age (≥65 years,OR =3. 05 ) were associated with mood disorders. Conclusion:Lifetime prevalence of any mental disorder,substance use disorders and anxiety disorders are high in Ximeng Wa Autonomous County. Measures should be strengthened against prevalence of mental disorders in ethnic minority areas.
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Objective:To explore the traits of gray matter volume in general anxiety disorder (GAD)and ob-sessive compulsive disorder (OCD)by using magnetic resonance imaging (MRI)technique.Methods:Twenty-eight GAD,25 OCD and 39 normal controls were recruited.All patients were met the Diagnostic and Statistical Mannal of Mental Disorders,Fourth Edition,Text Revision (DSM-IV-TR)or the International Statistical Classifica-tion of Disease and Related Health Problems Tenth Revision (ICD-10)diagnostic criteria for GAD or OCD.All subjects underwent structural MRI scan.The severity of anxiety and OCD symptoms were rated in all patients with the Hamilton Anxiety Rating Scale (HAMA)and the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).The gray matter volume (GMV)was compared between all groups by using the voxel-based morphometry (VBM)a- nalysis.The correlation analysis between GMV and total scores of HAMA and Y-BOCS was performed in GAD and OCD.Results:The GMV was increased in regions including left anterior cingulate cortex in GAD (P =0.016,small volume correction),while only decreased GMV was observed in OCD in bilateral orbitofrontal cortex (OFC)(P <0.001,uncorrected).GAD had larger GMV than OCD in several regions including bilateral OFC (P <0.001,un-corrected).The higher total score of HAMA was associated with increased GMV of right temporal cortex in GAD, and with the GMV of OFC in OCD (P <0.001,uncorrected).Conclusion:No sharing of GMV abnormalities in GAD and OCD was observed in the current study.The traits of brain structure and the potential neural substrate of anxiety symptom in GAD and OCD may be significantly different.
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Objective:To describe the epidemiological characteristics of mental disorders in community resi-dents aged 18 years and over in the Chifeng City of Inner Mongolia Autonomous Region.Methods:Six thousand three hundred and seventy six individuals aged 18 years and over were sampled using stratified Probability-Propor-tional-to-Size Sampling in Chifeng City in 2010.All respondents were investigated by face-to-face interview.The Composite International Diagnostic Interview-3.0 Computer Assisted Personal Interview (CIDI-3.0-CAPI)was used to make diagnoses based on the definition and criteria of the Diagnostic and Statistical Manual of Mental Dis-orders,Fourth Edition (DMS-IV).Results:A total of 4528 subjects completed the CIDI-3.0-CAPI.Regarding anxi-ety disorder,mood disorder,substance use disorder,and impulse control disorder,the 30-day adjusted prevalence rates (95%CI)were 2.5%(2.08% -2.99%,0.9%(0.67% -1.23%),0.5%(0.34% -0.76%),and 0.6%(0.41% -0.86%)respectively,and the 12 -month prevalence rates were 4.5% (3.93% -5.15%),2.4%(2.0% -2.90%),1.1% (0.84% -1.45%),and 1.0% (0.74% -1.32%)respectively.The lifetime adjusted prevalence rates were 6.6% (5.92% -7.36%),6.5% (5.81% -7.24%),2.7% (2.26% -3.21%),and 1.4%(1.23% -1.95%)respectively.Conclusion:According to morbidity,anxiety disorders,mood disorder,substance use disorders and impulse control disorders are common in Chifeng City of Inner Mongolia Autonomous Region se-quencely,being a prominent public health problem.
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<p><b>OBJECTIVE</b>To describe the prevalence and characteristics of mental disabilities in China.</p><p><b>METHODS</b>The data from the Second National Sample Survey on Disability were analyzed with descriptive epidemiological method and the overall prevalence rates of mental disabilities were statistically calculated.</p><p><b>RESULTS</b>Among 2 526 145 respondents, 15 155 of them more than 15 years old were diagnosed as mental disabilities, with the prevalence rate as 6.01‰. The prevalence rate of disabilities caused only by mental disorders was 4.57‰ with 11 501 more than 15 years old. The prevalence rate of disability caused only by mental disorders was 4.67‰ with 11 501 adults. Of the disability cases that exclusively caused by mental disorders, 64.58% of them were attributable to schizophrenia, schizotypal or delusional disorders, 6.28% were mood disorder, and 6.27% were epilepsy disability, followed by neurotic, stress-related and somatoform disorders (5.95%), dementia (5.19%), and other disabilities (less than 11.74%). Disabilities that attributable to schizophrenia, schizotypal and delusional disorders caused most severe impairments of functions in daily and social activities, followed by disabilities attributable to dementia, non-dementia organic mental disorder and epilepsy disability. Dementia caused the most severe grade of disability, accounted for 44.89% of all the cases. The data also showed that the disabilities attributable to mood disorder and neurotic, stress-related and somatoform disorder showed more impairments among mental disabilities.</p><p><b>CONCLUSION</b>Prevalence of mental disability in the second sample survey was higher than that of the first survey. Schizophrenia accounted for most of the mental disabilities but dementia caused the severest disability among all the cases with mental problems. As two of main causes of mental disabilities, neurosis and anxiety disorders should also be paid attention to.</p>
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Adolescent , Adult , Humans , Middle Aged , China , Epidemiology , Disabled Persons , Intellectual Disability , Epidemiology , Mental Disorders , Epidemiology , PrevalenceABSTRACT
Objective:To evaluate the test-retest reliability and validity of Chinese version of World Health Organization Composite International Diagnostic Interview version 3.0(CIDI-3.0)by community-based study.Methods:Among 202 subjects from Dalian city,with the clinician-administered Structured Clinical Interview for DSM-IV(SCID),102 patents were diagnostic as mood disorder,anxiety disorder,schizophrenia or psychotic disorder and so on.All of the patients and the other 100 subjects without mental disorders as the control group were interviewed blindly by CIDI-3.0 to test the validity of CIDI-3.0.Ten patients among them were interviewed twice independently in a 7-day interval to evaluate the reliability of CIDI-3.0.Results:(1)For the screen section,the sensitivity values of different mental disorders ranged from 60.4% to 93.1%,while the specificity values from 33.6% to 92.7%.The positive predictive values were from 60.1% to 95.1%,and the negative predictive values were from 68.1% to 93.7%.(2)For different mental disorders,the specificity values ranged from 97.1% to 98.9%,while the sensitivity values were from 33.3% to 70.3%.Positive predict values were from 66.7% to 95.7%,and negative predictive values were from 87.7% to 95.4%.(3)The consistency was 0.78 in any mental disorder.(4)For test-retest reliability,kappa values ranged from 0.737 to 1.0.Conclusion:By clinical reappraisal,the Chinese version of CIDI-3.0 has satisfied validity and reliability.The screen section has high sensitivity,while the diagnostic sections have high specificities.That indicates that CIDI-3.0 is acceptable as a validated instrument for community survey on mental disorders.
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Objective: To screen out suspected risk factors associated with neurosis, such as personality dis-order, life events, parental rearing behavior, and to explore degree of their associations. Methods: A case-control study was carried out among 100 cases with neurosis and 200 controls without mental disorder, matched by gender and age (+3 years) . The Life Events Scale (LES), Parental Rearing Style Questionnaire (EMBU), Personali-ty Diagnostic Questionnaire (PDQ-4) were self-reported by the subjects. Results: Single factor analysis showed that there were statistical differences (P <0.05) between case and control groups in negative life event (22.5 vs. 2.5), paternal rejection [(40.4±14.1) vs.(35.4±7.9)], paternal overprotection [(29.1±7.5)vs.(28.2±5.6)], maternal rejection rearing behavior [(40.4±13.7)vs.(36.8±8.5)], and overall personality disorder [(29.8±14.1)vs.(17.1±13.0)] . Using non-conditional logistic regression analysis, the potential protective factor was positive events (OR=0.92, 95% CI:0.87-0.98), and the potential risk factors included negative live events (OR=1.06, 95% CI:1.04～1.08) and overall personality disorder (OR=4.84, 95% CI: 2.24～10.49) . Conclusion: Positive life event may be a protective factor for neurosis, while negative life e-vent and personality disorder may be risk factors.